諾維信公司R·塞吉亞獲國家專利權
買專利賣專利找龍圖騰,真高效! 查專利查商標用IPTOP,全免費!專利年費監控用IP管家,真方便!
龍圖騰網獲悉諾維信公司申請的專利木聚糖酶變體和編碼其的多核苷酸獲國家發明授權專利權,本發明授權專利權由國家知識產權局授予,授權公告號為:CN114761551B 。
龍圖騰網通過國家知識產權局官網在2025-09-12發布的發明授權授權公告中獲悉:該發明授權的專利申請號/專利號為:202080083579.6,技術領域涉及:C12N9/24;該發明授權木聚糖酶變體和編碼其的多核苷酸是由R·塞吉亞;A·V·施旺格;S·達拉爾;K·詹森;L·奧爾森;K·B·R·M·克羅格;M·M·舒普;B·小維達爾設計研發完成,并于2020-12-17向國家知識產權局提交的專利申請。
本木聚糖酶變體和編碼其的多核苷酸在說明書摘要公布了:本發明涉及親本木聚糖酶的木聚糖酶變體,與該親本木聚糖酶相比,這些木聚糖酶變體具有增加的熱穩定性。本發明還涉及編碼這些變體的多核苷酸,包含這些多核苷酸的核酸構建體、載體和宿主細胞,以及產生本發明的變體的方法。
本發明授權木聚糖酶變體和編碼其的多核苷酸在權利要求書中公布了:1.一種親本木聚糖酶的木聚糖酶變體,該木聚糖酶變體在對應于SEQIDNO:1的位置45和149的兩個位置處包含取代,并且其中所述變體具有木聚糖酶活性,并且其中所述變體以SEQIDNO:1的多肽為基礎并且其取代由以下取代的組合中的任意一個組成: V45L+Q61K+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+A286E+H358D+A364G+Q384A+S388K+V393H+D470T+R483V; V45L+Q61K+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+Q384A+S388K+G394Q+D470T+R483V; V45L+Q61K+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+Q384A+S388K+G394A+D470T+R483V; V45L+Q61K+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+Q384A+S388K+V393H+D470T+R483V; V45L+A79C+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A79C+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+Q61K+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V+L530R; V45L+Q61K+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+L530R; V45L+Q61K+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+D470T+R483V+L530R; V45L+A117S+L149R+G187K+S214Q+V258P+A276S+A286E+H358D+A364G+Q384A+S388K+V393H+D470T+R483V; V45L+A117S+L149R+G187K+S214Q+V258P+A276S+A286E+H358D+A364G+Q384A+S388K+N395D+D470T+R483V; V45L+A117S+L149R+G187K+S214E+T215I+V258P+A276S+A286E+H358D+A364G+S388K+V393H+D470T+R483V; V45L+A117S+L149R+G187K+S214E+T215I+V258P+A276S+A286E+H358D+A364G+S388K+N395D+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+Q385C+S388K+D470T+R483V; V45L+Q61K+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A79C+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+T366I+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+Q384A+S388K+D470T+L530R; V45L+Q61K+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+V393H+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+G394A+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+V393H+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+A286E+H358D+A364G+S388K+D470T+R483V; D11E+V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+C468V+D470T+R483V; V45L+A79C+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T V45L+A79C+L149R+S214E+V258P+A276S+A364G+S388K; V45L+A117S+L149R+G187L+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+Q384A+S388K+D470T+R483V; V45L+A117S+L149R+G187K+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214E+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+G187L+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+G394Q+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+G394A+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+T366V+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+G394Q+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+S282N+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+N395D+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+N476D+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+V350L+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+T477K+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+Q496R; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+C468A+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+W495E; V45L+A117S+L149R+S214Q+V258P+A276S+A286E+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+G187K+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+Y391V+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; D9E+V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+T477V+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+V393R+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+T480L+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+S481A+L530R; V45L+A117S+L149R+S214Q+W250Y+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+S481A+R483V; V45L+A117S+L149R+S173Y+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+T70R+A117S+L149R+S214Q+C243V+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+A117S+L149R+T180Q+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; D11E+V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214E+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+N476D+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+A286S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276Q+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+Q496E; V45L+Q61R+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+Q314A+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276Q+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L478P+R483V; A25W+V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+T180Q+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+L484K V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+N474G+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+N395D+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+T366V+S388K+D470T+R483V; V45L+A117S+L149R+N168G+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+L484S; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+L484D; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+S528H; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+S501N; V45L+A117S+L149R+S173Y+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+A499L; V45L+S92D+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+Q314A+H358D+A364G+S388K+D470T+R483V; V45L+A79C+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+N355G+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+V350L+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+Q496E+L530R; V45L+A117S+L149R+N168G+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+V498I+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470A+R483V; V45N+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+A499Y; V45L+A79C+L149R+V258P+A276S+Q314A+A364G+S388K; V45L+A79C+L149R+V258P+A276S+L281V+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A286S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+S501N+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+T477V+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388H+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L478N+L530R; V45L+S92D+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+V500T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+V500T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L478P+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+S501E; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+D525L+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+G526T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+N527H+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+T477K+L530R; M28P+V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; D9E+V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+S501E+L530R; V45L+A117S+L149R+S214Q+W250Y+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+A499L+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+A472I+L530R; V45L+A117S+N127D+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+N527H; V45N+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+T480N+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+V497P; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+V498I; V45L+A79C+L149R+S173Y+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+T480N+R483V; V45L+A117S+L149R+S214Q+H219V+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388A+D470T+L530R; M28P+V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+A170S+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A79C+L149R+G187K+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+S389H+D470T+L530R; V45L+D113T+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+N163H+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388A+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388L+D470T+R483V; V45L+Q61R+A79C+L149R+V258P+A276S+A364G+S388K; V45L+A79C+L149R+N168G+V258P+A276S+A364G+S388K; V45L+A117S+L149R+T211H+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A79C+L149R+T215V+V258P+A276S+A364G+S388K; V45L+A79C+L149R+V258P+A276S+A286S+A364G+S388K; V45L+A79C+L149R+H219V+V258P+A276S+A364G+S388K; V45L+A79C+L149R+A170S+V258P+A276S+A364G+S388K; V45L+D113T+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+Q61K+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+D95N+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+G394A+D470T; V45L+A79C+L149R+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+G394A+D470T+R483V; V45L+A93T+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+A499Y; V45L+A117S+L149R+S214Q+T215I+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+H219I+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L478N; V45L+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214E+V258P+A276S+H358D+A364G+S388K+D470T; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+C468L+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+Q385C+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+T366I+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+S473G; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L478P; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+G394D+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+Q384A+S388K+D470T+R483V; D11E+V45L+A79C+L149R+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+N529T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+G394Q+D470T; V45L+A117S+L149R+G187L+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A79C+L149R+V258P+A276S+A286E+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+G503L; V45L+A117S+L149R+S214Q+V258P+A276S+Q314A+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+V350L+H358D+A364G+S388K+D470T; V45L+A117S+L149R+G187K+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+W250Y+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A286E+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+Q384A+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388R+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+S528H; V45L+A117S+L149R+S214Q+T215V+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+Q496R; V45L+A117S+L149R+N163H+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+S282N+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276Q+H358D+A364G+S388K+D470T; D11E+V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+T366V+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+S473K; V45L+A79C+L149R+T180Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388R+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+Q314A+A364G+S388K+D470T+R483V; V45L+S92D+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+N260H+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+G187S+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+T477K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+N474G; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+N395D+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+S501N; V45L+A117S+N127D+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+V393R+D470T; V45L+A117S+L149R+S173Y+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388H+D470T; V45L+A117S+L149R+S214Q+T215V+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+G187S+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+T211H+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+T480N; V45L+A117S+L149R+N168G+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A79C+L149R+H219I+V258P+A276S+A364G+S388K; V45L+L149R+S214E+V258P+A276S+H358D+A364G+D470T; V45L+Q61K+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+D113T+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+T366V+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358T+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+V393R+D470T+R483V; V45N+A79C+L149R+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+G394Q+D470T+R483V; V45L+A79C+L149R+V258P+A276S+V350L+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+T366I+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+G526T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L484S; V45L+A79C+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+A499L; V45L+A117S+L149R+S214Q+V258P+A276S+H358T+A364G+S388K+D470T+L530R; V45L+A79C+D113T+L149R+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+D525L; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+V498I; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388L+D470T; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+S528H+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+N476D+R483V; D9E+V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+S501E; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+S481A; V45L+A117S+L149R+S214Q+H219V+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+G187K+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+N395D+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+I469T+D470T+R483V; V45L+A79C+N127D+L149R+V258P+A276S+A364G+S388K; D9E+V45L+A79C+L149R+V258P+A276S+A364G+S388K; V45L+A117S+L149R+G187L+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+N529T+L530R; V45L+A79C+L149R+W250Y+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+V497P; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+N527H; V45L+A117S+L149R+N168G+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+T477V+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+V350L+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+L478N+R483V; V45L+A117S+L149R+S214E+V258P+A276S+A364G+S388K+D470T+R483V; M28P+V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+V393H+D470T+R483V; V45L+Q61R+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+V497P; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+V498I; V45L+A117S+L149R+S214Q+V258P+A276S+S282N+H358D+A364G+S388K+D470T+L530R; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+C375V+S388K+G394A+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A286E+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388R+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470A+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+T477K+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+Q496E; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+Q496R; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+A499L; V45L+A117S+L149R+S214Q+T215I+V258P+A276S+H358D+A364G+S388K+D470T; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+C468S+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+Y391V+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276Q+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+G503L+L530R; V45L+A117S+L149R+S214Q+H219I+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+N476D; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+V393H+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A286S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+S501E; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+N529T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+S501N; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+S481A+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+L478P+R483V; D11E+V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+T477V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+V497P+L530R; V45L+A117S+L149R+T211H+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Y+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+W250Y+V258P+A276S+A364G+S388K+D470T+R483V; V45L+S92D+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+N527H; V45N+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+Q385C+S388K+D470T; V45L+A117S+L149R+S173Y+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388H+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+S389H+D470T+R483V; V45L+A117S+L149R+S214Q+H219V+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A79C+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+T215I+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+Q496E; V45L+A117S+L149R+A170S+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+S389V+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+S389V+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388A+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+S389V+D470T; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+H219I+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A79C+L149R+N163H+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+A499Y; V45L+A117S+L149R+S214Q+V258P+A276S+L281V+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+V500T; V45L+A117S+L149R+T180Q+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+V500T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+G526T; V45L+C60L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+C69L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388A+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A286S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+V497D; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470A+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+D525L; V45L+A117S+L149R+S214Q+V258P+A276S+L281V+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+Q384A+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A286E+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+T477K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+S389H+D470T; V45L+A117S+L149R+S214Y+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Y+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+G394A+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+N476D; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L478N+R483V; V45L+C60A+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+V393H+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+N395D+D470T; A25W+V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+T70R+A117S+L149R+S214Q+C243L+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358T+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+L478N; V45L+C60S+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+A117S+L149R+S214Q+W250Y+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+T215V+V258P+A276S+A364G+S388K+D470T+R483V; V45L+Q61R+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+G187L+S214Q+V258P+A276S+A364G+S388K+D470T; D9E+V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G; V45L+C69A+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+T70R+A117S+L149R+C161S+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+A117S+L149R+S214Q+H219I+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+S282N+A364G+S388K+D470T; V45L+A117S+L149R+T211H+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+D95N+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+S473G; V45L+T70R+D95N+A117S+L149R+S214Q+V258P+A276S+L356M+H358D+A364G+S388K; D11E+V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+G394D+D470T; V45L+Q61K+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+G503L; V45L+A117S+L149R+S214Q+V258P+A276S+A286S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470A; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+G394Q+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388R+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+L478P; V45L+A117S+L149R+S214Q+V258P+A276S+V350L+A364G+S388K+D470T; V45L+D113T+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+T180Q+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+C69V+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+D525L; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+S389H+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+V393R+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+Q496R; V45L+A117S+N127D+L149R+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+A499Y; V45L+A117S+L149R+S214Q+T215V+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+T480L; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388L+D470T; V45L+A117S+L149R+S173Y+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+S92D+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+S389V+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+N529T; V45L+C60V+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+V497E; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+L478N; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T; M28P+V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276Q+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470V+R483V; V45L+A117S+L149R+S214Y+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+N395D; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+T477K; V45L+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K; V45L+Q61R+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+T215I+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+Q496E; V45L+A117S+L149R+G187K+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+W495I; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+V498I; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470K+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+V500T; D11E+V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+A117S+L149R+A170S+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+Y391V+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+Q314A+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+T477V; A25W+V45L+A79C+L149R+S214E+V258P+A276S+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+G394Q; V45L+A117S+L149R+S214Q+H219V+V258P+A276S+A364G+S388K+D470T; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+C375A+S388K+G394A+D470T+R483V; V45L+A117S+L149R+D192E+S214Q+V258P+A276S+H358D+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+A472L; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+A499Y; V45L+A117S+L149R+S214Q+T215V+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+Q385C+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388A+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388H+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+T480N; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+V497P; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+A499L; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+S501N; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+Q384A+S388K; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+C375S+S388K+G394A+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388L+D470T+R483V; V45L+A79C+S92D+L149R+V258P+A276S+A364G+S388K; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V+C540A; V45N+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+G394A; V45L+C69S+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+V498I; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G; V45L+A117S+L149R+S214Q+H219I+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+N163H+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+L149R+S214Q+V258P+A276S+H358D+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+Q314A+H358D+A364G+S388K; V45L+A117S+L149R+S173Y+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+A117S+L149R+S214E+V258P+A276S+H358D+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+G394D; A25W+V45L+A79C+L149R+V258P+A276S+A364G; V45L+L149R+S214Q+V258P+A276S+A286E+A364G+S388K; V45L+Q61R+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+T366V+S388K; V45L+A117S+L149R+D192E+S214Q+V258P+A276S+H358D+A364G; V45L+A117S+L149R+T180Q+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+A117S+L149R+S214Q+T215I+V258P+A276S+H358D+A364G+S388K; V45L+A117S+L149R+S214Q+W250Y+V258P+A276S+H358D+A364G+S388K; V45L+L149R+S214Q+T215I+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+N476D; V45L+D113T+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+T215K+V258P+A276S+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+T477V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+L478P; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+S481A; A25W+V45L+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+T211H+S214Q+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+T215K+V258P+A276S+H358D+A364G+S388K+D470T+R483V; V45L+A79C+L149R+V258P+A276S+L281V+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+V500T; V45L+A117S+L149R+S214Q+V258P+A276S+V350L+H358D+A364G+S388K; V45L+A117S+L149R+G187K+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+C375L+S388K+G394A+D470T+R483V; V45L+L149R+A170S+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214E+V258P+A276S+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470V+R483V; V45L+Q61K+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+L149R+N168G+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+N163H+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+A79C+D95D+L149R+V258P+A276S+A364G+S388K; V45L+Q77E+A79C+L149R+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+V497W; V45L+L149R+S214Q+V258P+A276S+S282N+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388R; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V+C540L; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V+C522S; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+W495S; V45L+L149R+S214Q+V258P+A276S+Q314A+A364G+S388K; V45L+D113T+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+V497W; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V+C540S; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+C396S+D470T+R483V; V45L+T70R+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+N474G; V45L+A117S+L149R+S214Q+V258P+A276S+S282N+H358D+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+S389V+D470T; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+C396A+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+S501E; A25W+V45L+L149R+S214E+V258P+A276S+A364G; V45L+L149R+S214Q+W250Y+V258P+A276S+A364G+S388K; V45L+L149R+G187K+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+S473K; V45L+A117S+L149R+G187L+S214Q+V258P+A276S+H358D+A364G+S388K; C40L+V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+Q496E; A25W+V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+L149R+V258P+A276S+L281V+H358T+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388A; V45L+A117S+L149R+N168G+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+S389H; M28P+V45L+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+T480L; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+Q384A+S388K; V45L+A93S+L149R+A252S+H334D; C40A+V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+L149R+G187L+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+Q385C+S388K; V45L+L149R+S214Q+V258P+A276S+A286S+A364G+S388K; V45L+S92D+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388L; V45L+A117S+L149R+S214Q+V258P+A276S+A286E+A364G+S388K; D9E+V45L+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+L149R+S173Y+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+A170S+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+Y391V; V45L+A117S+L149R+S214Q+V258P+A276S+L281V+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+G394D; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+S473G; V45L+A79C+L149R+V258P+A276S+H358T+A364G+S388K; V45L+L149R+S214Q+V258P+A276Q+A364G+S388K; A25W+V45L+L149R+S214E+V258P+A276S+H358T+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+T480N; D9E+V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+A117S+L149R+S214Q+H219I+V258P+A276S+H358D+A364G+S388K; C40S+V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; C40V+V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; A25W+V45L+L149R+S214E+V258P+A276S+A286E+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+G394A; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+A499L; A25W+V45L+Q61K+L149R+S214E+V258P+A276S+A364G; V45L+A117S+L149R+S214Q+T215V+V258P+A276S+H358D+A364G+S388K; A25W+V45L+L149R+V258P+A276S+H358T+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+R483V+W495E; A25W+V45L+A79C+L149R+V258P+A276S; V45L+L149R+S214Q+V258P+A276S+V350L+A364G+S388K; D11E+V45L+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+L149R+H219I+V258P+A276S+H358T+A364G+S388K; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+C396V+D470T+R483V; V45N+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+H219V+V258P+A276S+H358D+A364G+S388K; V45N+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+S92D+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+L149R+V258P+A276S+H358T+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+L478P; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+S481A; V45L+A117S+L149R+S214Q+V258P+A276S+Q314A+A364G+S388K; A25W+V45L+L149R+T211H+S214E+V258P+A276S+A364G; A25W+V45L+L149R+S214E+H219V+V258P+A276S+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+S389V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+V393H; V45L+A117S+L149R+S214Q+V258P+A276Q+H358D+A364G+S388K; V45L+A117S+N127D+L149R+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+L149R+W250Y+V258P+A276S+H358T+A364G+S388K; D9E+V45L+L149R+V258P+A276S+H358T+A364G+S388K; V45L+L149R+H219V+V258P+A276S+H358T+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+A472L; A25W+V45L+L149R+V258P+A276S+A364G; V45L+A117S+L149R+G187K+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+L478N; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+V393R; V45L+A117S+L149R+S214E+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+T366V+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358T+A364G+S388K; D11E+A25W+V45L+L149R+S214E+V258P+A276S+A364G; V45L+T70R+A117S+L149R+C161V+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+A117S+L149R+T211H+S214Q+V258P+A276S+H358D+A364G+S388K; V45L+L149R+V258P+A276S+Q314A+H358T+A364G+S388K; D11E+V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+G394Q; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+N395D; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+V393H; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+S501E; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+S528H; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388L; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+C396L+D470T+R483V; V45L+L149R+T180Q+S214Q+V258P+A276S+A364G+S388K; V45L+D113T+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+T480L; V45L+A93S+L149R+V234P+A252S; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388H; A25W+V45L+Q61R+L149R+S214E+V258P+A276S+A364G; V45L+A117S+L149R+S214Q+T215K+V258P+A276S+H358D+A364G+S388K+D470T; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+S389H; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+T366I+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+N474G; A25W+V45L+L149R+S214E+V258P+A276S+L281V+A364G; D9E+A25W+V45L+L149R+S214E+V258P+A276S+A364G; V45L+A117S+L149R+S214Q+T215K+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Y+V258P+A276S+H358D+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+V393R; V45L+Q61R+L149R+V258P+A276S+H358T+A364G+S388K; V45L+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+D113T+L149R+V258P+A276S+H358T+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A286S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388R; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+A499Y; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+V500T; V45L+Q61R+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+L149R+S214E+V258P+A276S+H358T+A364G; V45L+A117S+L149R+S214Q+V258P+A276Q+A364G+S388K; V45L+L149R+V258P+A276S+L281V+A364G; V45L+A117S+L149R+S214Q+W250Y+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+T480N; V45L+A117S+L149R+G187S+S214Q+V258P+A276S+A364G+S388K; A25W+V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K; A25W+V45L+L149R+S214E+V258P+A276Q+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+N476D; V45L+L149R+S214Q+V258P+A276S+L281V+A364G; V45L+A93S+L149R+A252S+H334D+A340G; V45L+L149R+A252S+H334D; V45L+N127D+L149R+V258P+A276S+A364G+S388K; V45L+L149R+V258P+A276S+H358T+A364G+S388K; V45L+L149R+V258P+A276S+A364G+S388K; D9E+V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+L149R+N168G+V258P+A276S+A364G; V45L+L149R+T180Q+V258P+A276S+H358T+A364G+S388K; V45L+L149R+G187L+V258P+A276S+A364G+S388K; V45L+L149R+W250Y+V258P+A276S+A364G+S388K; V45L+L149R+V258P+A276S+A286E+A364G+S388K; V45L+L149R+V258P+A276S+S282N+A364G+S388K; A25W+V45L+L149R+V258P+A276S+A364G+S388K; V45L+L149R+S214Q+V258P+A276S+H358T+A364G; V45L+L149R+S173Y+V258P+A276S+A364G; V45L+A117S+L149R+S214Q+H219V+V258P+A276S+A364G+S388K; V45L+A93S+L149R+A252S+H334D+A340G; V45L+L149R+S190E+D446T+R459V; A25W+V45L+L149R+V258P+A276S+H358T; A25W+V45L+S92D+L149R+S214E+V258P+A276S+A364G; A25W+V45L+L149R+S214E+V258P+A276S+V350L+A364G; A25W+V45L+L149R+S214Q+V258P+A276S+A364G; V45L+L149R+N168G+V258P+A276S+A364G+S388K; V45L+A117S+L149R+V258P+A276S+A364G+S388K; A25W+V45L+L149R+V258P+A276S+H358T+A364G; V45L+L149R+V258P+N260H+A276S+A364G+S388K; V45L+L149R+T215I+V258P+A276S+A364G+S388K; A25W+V45L+L149R+V258P+A276Q+A364G; V45L+T70R+A117S+L149R+C161L+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; A25W+V45L+L149R+S214E+V258P+A276S; V45L+A117S+L149R+S214Q+V258P+A276S+A286S+H358D+A364G+S388K; V45L+L149R+T211H+S214Q+V258P+A276S+A364G+S388K; V45L+Q61K+L149R+V258P+A276S+H358T+A364G; V45L+L149R+V258P+A276S+Q314A+H358T+A364G; V45L+L149R+T180Q+V258P+A276S+A364G+S388K; V45L+L149R+V258P+A276S+Q314A+A364G+S388K; A25W+V45L+L149R+V258P+A276S+A286S+A364G; V45L+L149R+S190E+D446T; V45L+L149R+V258P+A276S+A364G; V45L+L149R+A170S+V258P+A276S+A364G; V45L+L149R+V258P+A276Q+A364G; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V+C522A; V45L+L149R+H219I+V258P+A276S+H358T+A364G; V45L+L149R+V258P+A276S+V350L+A364G+S388K; D11E+V45L+L149R+V258P+A276S+A364G+S388K; V45L+D113T+L149R+V258P+A276S+A364G+S388K; V45L+L149R+G187K+V258P+A276S+A364G+S388K; M28P+V45L+L149R+V258P+A276S+A364G+S388K; V45L+Q61R+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V; A25W+V45L+L149R+S214Q+V258P+A276S; V45L+A117S+L149R+S214Q+T215I+V258P+A276S+A364G+S388K; A25W+V45L+L149R+V258P+A276S+S388K; A25W+V45L+L149R+S214E+H219I+V258P+A276S+A364G; V45L+A93S+L149R+V234P+A252S+H334D; V45L+L149R+T211H+V258P+A276S+H358T+A364G+S388K; A25W+V45L+A117S+L149R+S214E+V258P+A276S+A364G; V45L+L149R+S173Y+V258P+A276S+A364G+S388K; A25W+V45L+L149R+V258P+A276S+Q314A+A364G; V45L+L149R+G187L+V258P+A276S+H358T+A364G; V45L+L149R+T215V+V258P+A276S+H358T+A364G; V45L+T70R+L149R+V258P+A276S+A364G+S388K; V45L+N127D+L149R+V258P+A276S+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+Q496R; V45L+L149R+W250Y+V258P+A276S+A364G; V45L+L149R+V258P+A276S+V350L+H358T+A364G; D9E+V45L+L149R+V258P+A276S+H358T+A364G; V45L+L149R+T211H+V258P+A276S+H358T+A364G; A25W+V45L+L149R+W250Y+A276Q+A364G; V45L+L149R+V258P+A276S+L281V+A364G+S388K; V45L+L149R+V258P+A276S+S282N+H358T+A364G; V45L+L149R+T215I+V258P+A276S+H358T+A364G; A25W+V45L+L149R+S173Y+V258P+A276S+A364G; V45L+Q61K+L149R+V258P+A276S+A364G+S388K; V45L+L149R+T180Q+V258P+A276S+A364G; V45L+A117S+L149R+A170S+S214Q+V258P+A276S+A364G+S388K; V45L+Q61R+A117S+L149R+S214Q+V258P+A276S+A364G+S388K; A25W+V45L+L149R+S214E+T215V+V258P+A276S+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+V497P; V45L+L149R+V258P+A276S+Q314A+A364G; V45L+A117S+L149R+V258P+A276S+A364G; V45L+A117S+L149R+V258P+A276S+H358T+A364G+S388K; V45L+L149R+N168G+V258P+A276S+H358T+A364G+S388K; A25W+V45L+Q61K+L149R+V258P+A276S+A364G; V45L+L149R+S214E+V258P+A276S+L281V+A364G; V45N+L149R+V258P+A276S+A364G+S388K; V45L+L149R+V258P+A276S+A286E+H358T+A364G; D9E+V45L+L149R+V258P+A276S+A364G+S388K; V45L+S92D+L149R+V258P+A276S+A364G+S388K; V45L+A117S+L149R+T180Q+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388H; V45L+A117S+L149R+S214Q+T215V+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+V350L+A364G+S388K; A25W+V45L+L149R+S214E+T215I+V258P+A276S+A364G; V45L+N127D+L149R+V258P+A276S+H358T+A364G+S388K; A25W+V45L+L149R+V258P+A276S+A286E+A364G; V45L+L149R+N168G+V258P+A276S+L281V+A364G; V45L+Q61R+L149R+V258P+A276S+H358T+A364G; V45L+L149R+G187S+V258P+A276S+A364G+S388K; V45L+L149R+V258P+A276S+L281V+Q314A+A364G; V45L+L149R+V258P+A276S+L281V+H358T+A364G; V45L+L149R+A170S+V258P+A276S+H358T+A364G; V45L+L149R+A170S+V258P+A276S+A364G+S388K; V45L+L149R+T215V+V258P+A276S+A364G+S388K; V45L+L149R+V258P+A276Q+L281V+A364G; V45L+T70R+A117S+L149R+S214Q+C243S+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V+C522V; A25W+V45L+L149R+V258P+A276S+Q314A; V45L+L149R+V258P+A276Q+H358T+A364G+S388K; A25W+V45N+L149R+S214E+V258P+A276S+A364G; V45L+L149R+V258P+A276S+A286E+A364G; V45L+L149R+V258P+A276S+A286S+H358T+A364G; A25W+V45L+L149R+G187S+V258P+A276S+A364G; V45L+L149R+T180Q+V258P+A276S+L281V+A364G; A25W+V45L+L149R+A276Q+L281V+A364G; V45L+S92D+L149R+V258P+A276S+L281V+A364G; V45L+Q61R+L149R+V258P+A276S+L281V+A364G; V45L+L149R+A170S+V258P+A276S+L281V+A364G; D11E+A25W+V45L+L149R+V258P+A276S+A364G; A25W+V45L+Q61R+L149R+V258P+A276S+A364G; A25W+V45L+L149R+T215V+V258P+A276S+A364G; D9E+V45L+L149R+V258P+A276S+L281V+A364G; A25W+V45L+L149R+V258P+A276S+V350L+A364G; V45L+Q61K+A117S+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+Y391V; V45L+A117S+L149R+N168G+S214Q+V258P+A276S+A364G+S388K; V45L+D113T+A117S+L149R+S214Q+V258P+A276S+A364G+S388K; A25W+V45L+L149R+V258P+A276S+A286E; A25W+V45L+L149R+V258P+A276S+L281V; A25W+V45L+D113T+L149R+V258P+A276S; V45L+L149R+H219V+V258P+A276S+L281V+A364G; V45L+L149R+T180Q+V258P+A276S+H358T+A364G; V45L+L149R+T215V+V258P+A276S+L281V+A364G; A25W+V45L+L149R+V258P+A276S+S282N+A364G; A25W+V45L+L149R+T215I+V258P+A276S+A364G; A25W+V45L+L149R+H219I+V258P+A276S+A364G; V45L+A117S+L149R+V258P+A276S+L281V+A364G; D9E+A25W+V45L+L149R+V258P+A276S+A364G; V45L+L149R+S214Y+V258P+A276S+A364G+S388K; A25W+V45L+L149R+T180Q+V258P+A276S+A364G; A25W+V45L+L149R+V258P+A276S+L281V+A364G; V45L+N127D+L149R+V258P+A276S+L281V+A364G; V45L+L149R+S173Y+V258P+A276S+H358T+A364G; V45L+Q61R+L149R+V258P+A276S+A364G+S388K; M28P+V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388A; V45N+A117S+L149R+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+T477K; A25W+V45L+L149R+T180Q+V258P+A276S; A25W+V45L+L149R+V258P+A276S+A286S; A25W+V45L+L149R+G187S+S214E+V258P+A276S+A364G; V45L+L149R+V258P+A276S+L281V+A286E+A364G; A25W+V45L+L149R+W250Y+V258P+A276S+A364G; A25W+V45L+L149R+V258P+N260H+A276S+A364G; V45L+L149R+V258P+A276S+L281V+V350L+A364G; A25W+V45L+L149R+A170S+V258P+A276S+A364G; V45L+L149R+V258P+A276S+L281V+A286S+A364G;V45L+L149R+V258P+A276S+L281V+S282N+A364G; D11E+V45L+L149R+V258P+A276S+L281V+A364G; V45L+Q61K+L149R+V258P+A276S+L281V+A364G; V45L+L149R+T215I+V258P+A276S+L281V+A364G; A25W+V45L+S92D+L149R+V258P+A276S+A364G; V45L+L149R+S214Y+V258P+A276S+L281V+A364G; V45L+L149R+T211H+V258P+A276S+L281V+A364G; A25W+V45L+L149R+G187L+V258P+A276S+A364G; V45L+S92D+L149R+V258P+A276S+H358T+A364G; V45L+L149R+G187L+A276Q+L281V+A364G; V45L+L149R+A276Q+L281V+V350L+A364G; V45L+L149R+A276Q+L281V+A364G+S388K; V45L+A117S+L149R+S214Y+V258P+A276S+A364G+S388K;A25W+V45L+S92D+L149R+V258P+A276S; A25W+V45L+L149R+G187L+V258P+A276S; A25W+V45L+L149R+W250Y+V258P+A276S; V45L+D113T+L149R+V258P+A276S+A364G; V45L+L149R+G187K+V258P+A276S+H358T+A364G; V45L+L149R+N163H+V258P+A276S+L281V+A364G; A25W+V45L+T70R+L149R+V258P+A276S+A364G; V45L+L149R+S173Y+V258P+A276S+L281V+A364G; V45L+L149R+G187L+V258P+A276S+L281V+A364G; V45L+L149R+G187K+V258P+A276S+L281V+A364G; V45L+L149R+W250Y+V258P+A276S+H358T+A364G; V45L+L149R+T211H+V258P+A276S+A364G+S388K; V45L+L149R+N163H+V258P+A276S+A364G+S388K; V45L+T70R+L149R+A276Q+L281V+A364G; V45L+S92D+L149R+A276Q+L281V+A364G; V45L+D113T+L149R+A276Q+L281V+A364G; V45L+L149R+A276Q+L281V+Q314A+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+S389V; A25W+V45L+Q61K+L149R+V258P+A276S; D9E+A25W+V45L+L149R+V258P+A276S; V45L+T70R+L149R+V258P+A276S+A364G; V45L+L149R+V258P+A276S+A286S+A364G+S388K; A25W+V45L+L149R+S214Y+V258P+A276S+A364G; A25W+V45L+D113T+L149R+V258P+A276S+A364G; V45L+T70R+L149R+V258P+A276S+L281V+A364G; A25W+V45L+N127D+L149R+V258P+A276S+A364G; V45L+T70R+L149R+V258P+A276S+H358T+A364G; V45L+L149R+N163H+V258P+A276S+A364G; V45L+L149R+T180Q+A276Q+L281V+A364G; V45L+L149R+A276Q+L281V+A286S+A364G; A25W+V45L+L149R+A170S+V258P+A276S; A25W+V45L+T70R+L149R+V258P+A276S; A25W+V45L+L149R+S214E+V258P+A276S+A286S+A364G; V45L+L149R+V258P+A276S+A286S+H358T+A364G+S388K; V45L+L149R+H219I+V258P+A276S+L281V+A364G; A25W+V45L+A117S+L149R+V258P+A276S+A364G; A25W+V45L+L149R+N168G+V258P+A276S+A364G; V45L+L149R+N168G+A276Q+L281V+A364G; V45L+L149R+S173Y+A276Q+L281V+A364G; V45L+L149R+W250Y+A276Q+L281V+A364G; V45L+A117S+L149R+S173Y+S214Q+V258P+A276S+A364G+S388K; A25W+V45L+L149R+A276Q+A286E+A364G; A25W+V45L+L149R+A276Q+A364G+S388K; V45L+N127D+L149R+V258P+A276S+H358T+A364G; A25W+V45L+L149R+V258P+A276S; V45L+N127D+L149R+A276Q+L281V+A364G; V45L+L149R+A276Q+L281V+A286E+A364G; A25W+V45L+A117S+L149R+V258P+A276S; A25W+V45L+L149R+H219V+V258P+A276S+A364G; V45L+L149R+S173Y+V258P+A276S+H358T+A364G+S388K; D11E+V45L+L149R+V258P+A276S+H358T+A364G; V45L+A79C+L149R+V258P+A276S+N355G+A364G+S388K; A24K+V45L+L149R+V258P+A276S+A364G; V45L+L149R+V258P+A276S+S282N+A364G; V45L+A117S+L149R+A276Q+L281V+A364G; V45L+L149R+N260H+A276Q+L281V+A364G; V45L+A117S+L149R+T211H+S214Q+V258P+A276S+A364G+S388K; A25W+V45L+L149R+N168G+V258P+A276S; A25W+V45L+L149R+G187S+V258P+A276S; A25W+V45L+L149R+V258P+A276S+V350L; A25W+V45L+Q61R+L149R+V258P+A276S; A25W+V45L+L149R+G187L+S214E+V258P+A276S+A364G; V45L+L149R+G187S+V258P+A276S+L281V+A364G; A25W+V45L+L149R+N163H+V258P+A276S+A364G; A25W+V45L+L149R+G187K+V258P+A276S+A364G; V45N+L149R+V258P+A276S+L281V+A364G; V45L+L149R+A276Q+L281V+A364G; V45L+L149R+V258P+N260H+A276S+H358T+A364G; V45L+L149R+A276Q+S282N+A364G; V45L+S92D+A117S+L149R+S214Q+V258P+A276S+A364G+S388K; A25W+V45L+L149R+V258P+A276S+S282N; A25W+V45L+L149R+S173Y+V258P+A276S; A25W+V45L+L149R+A276Q+A286S+A364G; V45L+D113T+L149R+V258P+A276S+L281V+A364G; V45L+L149R+S214Q+V258P+A276S+L281V+A364G+S388K; V45L+D113T+L149R+V258P+A276S+H358T+A364G; A25W+V45L+L149R+T215V+V258P+A276S; V45L+L149R+N168G+V258P+A276S+H358T+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+A472L; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+S473K; A25W+V45L+L149R+T215I+V258P+A276S; A25W+V45L+L149R+T211H+V258P+A276S; A25W+V45L+L149R+V258P+A276Q; V45L+L149R+S214Q+T215V+V258P+A276S+A364G+S388K; V45L+L149R+N163H+V258P+A276S+H358T+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+A499L; V45L+L149R+V258P+A276S+V350L+A364G; V45L+A79C+A117S+L149R+V258P+A276S+A364G+S388K; A25W+V45L+D113T+L149R+A276Q+A364G; A25W+V45N+L149R+V258P+A276S+A364G; V45L+T70R+L149R+A276Q+A364G; A25W+V45L+L149R+H219I+V258P+A276S; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+V498I; M28P+V45L+L149R+V258P+A276S+A364G; A25W+V45L+T70R+L149R+A276Q+A364G; A25W+V45L+L149R+A276Q+Q314A+A364G; V45L+L149R+A170S+V258P+A276S+H358T+A364G+S388K; A25W+V45L+L149R+S214Y+V258P+A276S; V45L+L149R+S214Y+V258P+A276S+H358T+A364G; V45L+L149R+A276Q+L281V+H358T+A364G; A25W+V45L+L149R+H219V+V258P+A276S; V45L+A117S+L149R+N163H+S214Q+V258P+A276S+A364G+S388K; D11E+A25W+V45L+L149R+V258P+A276S; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+N527H; A25W+V45L+A117S+L149R+A276Q+A364G; V45L+L149R+V258P+L281V+A364G; A25W+V45L+L149R+G187L+A276Q+A364G; V45N+L149R+V258P+A276S+H358T+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+N355G+H358D+A364G+S388K+D470T+R483V; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388H+D470T+R483V; A25W+V45L+L149R+A276Q+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+R483V+V497E; A25W+V45L+L149R+N163H+A276Q+A364G; A25W+V45L+L149R+S173Y+A276Q+A364G; A25W+V45L+L149R+A276Q+S282N+A364G; A25W+V45L+L149R+A276Q+H358T+A364G; A25W+V45L+L149R+T180Q+A276Q+A364G; V45L+A117S+L149R+V258P+A276S+H358T+A364G; V45L+L149R+A276Q+Q314A+A364G; V45L+L149R+G187K+V258P+A364G; V45L+L149R+A276Q+A286E+A364G; A25W+V45L+N127D+L149R+A276Q+A364G; A25W+V45L+L149R+A170S+A276Q+A364G; A25W+V45L+N127D+L149R+V258P+A276S; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+T477V; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+G503L; A25W+M28P+V45L+L149R+V258P+A276S+A364G; V45L+L149R+A276Q+H358T+A364G; A25W+V45L+L149R+N168G+A276Q+A364G; A25W+V45L+L149R+N260H+A276Q+A364G; V45L+A117S+L149R+G187L+S214Q+V258P+A276S+A364G+S388K; V45L+A117S+L149R+N163H+S214Q+V258P+A276S+H358D+A364G+S388K+D470T+L530R; V45L+A117S+L149R+S214Q+T215K+V258P+A276S+A364G+S388K; A25W+V45L+L149R+G187K+V258P+A276S; A25W+M28P+V45L+L149R+V258P+A276S; A25W+V45N+L149R+V258P+A276S; V45L+A117S+L149R+S214Q+V258P+A276S+N355G+H358D+A364G+S388K+D470T; V45L+N127D+L149R+A276Q+A364G; V45L+L149R+W250Y+A276Q+A364G; V45L+L149R+W250Y+V258P+A364G; V45L+L149R+N163H+A276Q+L281V+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+Q385C+S388K; A25W+V45L+L149R+S214E+T215K+V258P+A276S+A364G; M28P+V45L+L149R+V258P+A276S+L281V+A364G; V45L+L149R+A276Q+A364G+S388K; A25W+V45L+L149R+V258P+A364G; M28P+V45L+L149R+V258P+A276S+H358T+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+N355G+H358D+A364G+S388K; V45L+T70R+A117S+L149R+S214Q+V258P+A276S+L281V+H358D+A364G+S388K+G394A+D470T+R483V+C540V; V45L+L149R+N168G+A276Q+A364G; V45L+A117S+L149R+A276Q+A364G; V45L+L149R+N163H+V258P+A276S+H358T+A364G; V45L+L149R+T215K+V258P+A276S+H358T+A364G; A24K+V45L+L149R+A276Q+A364G; V45L+L149R+A276Q+A286S+A364G; V45L+L149R+V258P+A364G; V45L+L149R+H219I+V258P+A276S+A364G+S388K; V45L+L149R+A170S+A276Q+A364G; V45L+L149R+T180Q+A276Q+A364G; V45L+L149R+A276Q+V350L+A364G; V45L+L149R+V258P+S282N+A364G; V45L+L149R+A276Q+A364G; V45L+L149R+A276S+A364G; V45L+L149R+T215K+V258P+A276S+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+N355G+A364G+S388K+D470T; V45L+L149R+V258P+A276S; A25W+V45L+L149R+A276S+A364G; V45L+L149R+G187S+V258P+A364G; V45L+S92D+L149R+V258P+A276S+H358T+A364G+S388K; V45L+L149R+G187L+A276Q+A364G; V45L+L149R+N260H+A276Q+A364G; V45L+L149R+W250Y+V258R+A364G; V45L+L149R+N163H+A276Q+A364G; V45L+S92D+L149R+A276Q+A364G; V45L+L149R+S173Y+A276Q+A364G; V45L+S92D+L149R+V258P+A364G; V45L+L149R+W250Y+V258P+A276S+L281V+A364G; V45L+L149R+L281V+A364G; V45L+D113T+L149R+A276Q+A364G; V45L+L149R+G187S+V258R+A364G; V45L+L149R+V258R+A364G+S388K; A25W+V45L+L149R+A364G; V45L+L149R+G187K+V258R+A364G; V45L+L149R+V258P; V45L+L149R+V258R+S282N+A364G; V45L+L149R; V45L+L149R+V258R+L281V+A364G; V45L+L149R+A364G; V45L+L149R+S214Q+V258P+A276S+N355G+A364G+S388K; V45L+S92N+L149R+V258P+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+A286E+H358D+A364G+S388K; A25W+V45L+L149R+S214E+V258P+A276S+N355G+A364G; V45L+L149R+G187L+V258P+A276S+A364G; V45L+L149R+V258R+A364G; V45L+L149R+V258P+A364G+S388K; A25W+V45L+L149R+A276Q+V350L+A364G; V45L+L149R+H219V+V258P+A276S+A364G+S388K; V45L+L149R+G187K+A364G; V45L+L149R+G187S+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+N355G+A364G+S388K; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+Y386G+S388K+D470T+R483V; V45L+L149R+W250Y; V45L+S92N+L149R+V258R+A364G; A25W+V45L+L149R+V258P+A276S+N355G+A364G; V45L+L149R+V258P+A276S+N355G+A364G+S388K; V45L+L149R+G187S; V45N+L149R; V45L+L149R+S282N; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+S388K+G394D+D470T+R483V; V45L+S92D+L149R; V45L+L149R+W250Y+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+H358D+A364G+Y386G+S388K; V45L+L149R+V258P+A276S+L281V+N355G+A364G; V45L+L149R+V258P+A276S+N355G+H358T+A364G; V45L+L149R+V258P+A276S+N355G+A364G; A25W+V45L+L149R+V258P+A276S+N355G; A25W+V45L+S92D+L149R+A276Q+A364G; V45L+A117S+L149R+S214Q+V258P+A276S+A364G+S388K+D470T+S501E; V45L+L149R+H219V+V258P+A276S+H358T+A364G; A25W+V45L+L149R+A276Q+N355G+A364G; A25W+V45L+L149R+S214E+V258P+A276S+Q314A+A364G; 并且其中該木聚糖酶變體與SEQIDNO:1的木聚糖酶相比具有增加的熱穩定性。
如需購買、轉讓、實施、許可或投資類似專利技術,可聯系本專利的申請人或專利權人諾維信公司,其通訊地址為:丹麥鮑斯韋;或者聯系龍圖騰網官方客服,聯系龍圖騰網可撥打電話0551-65771310或微信搜索“龍圖騰網”。
1、本報告根據公開、合法渠道獲得相關數據和信息,力求客觀、公正,但并不保證數據的最終完整性和準確性。
2、報告中的分析和結論僅反映本公司于發布本報告當日的職業理解,僅供參考使用,不能作為本公司承擔任何法律責任的依據或者憑證。